Imaging Regional Metabolic Changes in the Ischemic Rat Heart In Vivo Using Hyperpolarized [1-13C]Pyruvate
نویسندگان
چکیده
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital Hvidovre, Denmark; 2Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; 3Department of Clinical Medicine, MR Research Centre, Aarhus University Hospital, Aarhus, Denmark; 4Neurobiology Research Unit, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; 5Department of Electrical Engineering, Technical University of Denmark, Kongens Lyngby, Denmark; and 6GE Healthcare, Brøndby, Denmark
منابع مشابه
Assessing ischemic myocardial metabolism in vivo with hyperpolarized 13C: relating the metabolic perturbation to the area at risk
Background The high metabolic activity of the heart makes it particularly suited to the use of hyperpolarized (HP) 13C methods to non-invasively detect and characterize metabolic changes that occur during ischemia/reperfusion (I/R). Energy metabolism in ischemic rat hearts has been previously interrogated with HP 13C-labelled pyruvate ex vivo, and its hyperpolarized metabolites have been imaged...
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